diff --git a/moto/ec2/models.py b/moto/ec2/models.py
index a7a34cbf..6666a964 100644
--- a/moto/ec2/models.py
+++ b/moto/ec2/models.py
@@ -3465,19 +3465,30 @@ class SubnetBackend(object):
         vpc = self.get_vpc(
             vpc_id
         )  # Validate VPC exists and the supplied CIDR block is a subnet of the VPC's
-        vpc_cidr_block = ipaddress.IPv4Network(
-            six.text_type(vpc.cidr_block), strict=False
-        )
+        vpc_cidr_blocks = [
+            ipaddress.IPv4Network(
+                six.text_type(cidr_block_association["cidr_block"]), strict=False
+            )
+            for cidr_block_association in vpc.get_cidr_block_association_set()
+        ]
         try:
             subnet_cidr_block = ipaddress.IPv4Network(
                 six.text_type(cidr_block), strict=False
             )
         except ValueError:
             raise InvalidCIDRBlockParameterError(cidr_block)
-        if not (
-            vpc_cidr_block.network_address <= subnet_cidr_block.network_address
-            and vpc_cidr_block.broadcast_address >= subnet_cidr_block.broadcast_address
-        ):
+
+        subnet_in_vpc_cidr_range = False
+        for vpc_cidr_block in vpc_cidr_blocks:
+            if (
+                vpc_cidr_block.network_address <= subnet_cidr_block.network_address
+                and vpc_cidr_block.broadcast_address
+                >= subnet_cidr_block.broadcast_address
+            ):
+                subnet_in_vpc_cidr_range = True
+                break
+
+        if not subnet_in_vpc_cidr_range:
             raise InvalidSubnetRangeError(cidr_block)
 
         for subnet in self.get_all_subnets(filters={"vpc-id": vpc_id}):
diff --git a/tests/test_ec2/test_subnets.py b/tests/test_ec2/test_subnets.py
index 2d30171f..416235f4 100644
--- a/tests/test_ec2/test_subnets.py
+++ b/tests/test_ec2/test_subnets.py
@@ -417,6 +417,24 @@ def test_create_subnet_with_invalid_cidr_range():
     )
 
 
+@mock_ec2
+def test_create_subnet_with_invalid_cidr_range_multiple_vpc_cidr_blocks():
+    ec2 = boto3.resource("ec2", region_name="us-west-1")
+
+    vpc = ec2.create_vpc(CidrBlock="10.0.0.0/16")
+    ec2.meta.client.associate_vpc_cidr_block(CidrBlock="10.1.0.0/16", VpcId=vpc.id)
+    vpc.reload()
+    vpc.is_default.shouldnt.be.ok
+
+    subnet_cidr_block = "10.2.0.0/20"
+    with assert_raises(ClientError) as ex:
+        subnet = ec2.create_subnet(VpcId=vpc.id, CidrBlock=subnet_cidr_block)
+    str(ex.exception).should.equal(
+        "An error occurred (InvalidSubnet.Range) when calling the CreateSubnet "
+        "operation: The CIDR '{}' is invalid.".format(subnet_cidr_block)
+    )
+
+
 @mock_ec2
 def test_create_subnet_with_invalid_cidr_block_parameter():
     ec2 = boto3.resource("ec2", region_name="us-west-1")
@@ -436,6 +454,46 @@ def test_create_subnet_with_invalid_cidr_block_parameter():
     )
 
 
+@mock_ec2
+def test_create_subnets_with_multiple_vpc_cidr_blocks():
+    ec2 = boto3.resource("ec2", region_name="us-west-1")
+    client = boto3.client("ec2", region_name="us-west-1")
+
+    vpc = ec2.create_vpc(CidrBlock="10.0.0.0/16")
+    ec2.meta.client.associate_vpc_cidr_block(CidrBlock="10.1.0.0/16", VpcId=vpc.id)
+    vpc.reload()
+    vpc.is_default.shouldnt.be.ok
+
+    subnet_cidr_block_primary = "10.0.0.0/24"
+    subnet_primary = ec2.create_subnet(
+        VpcId=vpc.id, CidrBlock=subnet_cidr_block_primary
+    )
+
+    subnet_cidr_block_secondary = "10.1.0.0/24"
+    subnet_secondary = ec2.create_subnet(
+        VpcId=vpc.id, CidrBlock=subnet_cidr_block_secondary
+    )
+
+    subnets = client.describe_subnets(
+        SubnetIds=[subnet_primary.id, subnet_secondary.id]
+    )["Subnets"]
+    subnets.should.have.length_of(2)
+
+    for subnet in subnets:
+        subnet.should.have.key("AvailabilityZone")
+        subnet.should.have.key("AvailabilityZoneId")
+        subnet.should.have.key("AvailableIpAddressCount")
+        subnet.should.have.key("CidrBlock")
+        subnet.should.have.key("State")
+        subnet.should.have.key("SubnetId")
+        subnet.should.have.key("VpcId")
+        subnet.shouldnt.have.key("Tags")
+        subnet.should.have.key("DefaultForAz").which.should.equal(False)
+        subnet.should.have.key("MapPublicIpOnLaunch").which.should.equal(False)
+        subnet.should.have.key("OwnerId")
+        subnet.should.have.key("AssignIpv6AddressOnCreation").which.should.equal(False)
+
+
 @mock_ec2
 def test_create_subnets_with_overlapping_cidr_blocks():
     ec2 = boto3.resource("ec2", region_name="us-west-1")